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. 2019 Jan 10;8(3):1535293. doi: 10.1080/2162402X.2018.1535293

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© 2019 Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Composition of tumor-infiltrating lymphocytes in tumors stratified according to serological TAA antibody detection.

Single cell suspensions from HNSCC tumor tissue (n = 38) were analyzed for B and T cell antigens by flow cytometry. Patients were stratified according to serological antibody detection against 23 TAAs in TAA⁻ (no antibody response detected) and TAA⁺ (detection of antibodies against at least one investigated TAA). (A) The fraction of CD19⁺/CD20⁺ B cells (left) and plasmacells (CD27⁺/CD38^hi/CD138^hi/CD20⁻; right) in the microenvironment of TAA⁻ and TAA⁺ tumors is displayed in scatter plots. (B) Proportions of CD3⁺ T cells within the CD45⁺ lymphocyte fraction are shown in scatter plots in TAA⁻/⁺ tumors. (C) Scatter plots demonstrate fractions of CD8⁺ T cells (left), CD4⁺ T cells (middle) and T helper cells (CXCR5⁺/CD45RA⁻/CCR7⁻) in percent of CD4⁺ T cells (right) in TAA⁻/⁺ HNSCC. For statistical analysis, Mann-Whitney test was performed in (A), t test in (B) and (C). Data is presented as mean. *P < 0.05; **P < 0.005; ns, not significant.