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BMP4 is down-regulated in hMSC-AML. To verify the BMP4 expression, we used RT-qPCR assay to determine changes in the mRNA expression obtained from hMSC-AML and from hMSC-HD cultures. Data normalization was performed using the endogenous genes B2M and GAPDH. The bars indicate the mean mRNA levels (± standard deviation). **** P <0 .0001. hMSC-HD: mesenchymal stromal cells derived from healthy donors; hMSC-AML: mesenchymal stromal cells derived from AML patients.
