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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Biomaterials. 2018 Dec 31;195:111–123. doi: 10.1016/j.biomaterials.2018.12.031

Figure 7.

Figure 7.

In situ forming PEG/PEI hydrogels elicit a unique meningeal inflammatory response. (a) Meningeal CX3CR1(+) cells show robust migration through the PEG/PEI gel for at least 1 to 14 days post implant. Superimposed images at earlier time points (red) and later timepoints (green) show migrating cells as distinct red and green elements (denoted by white “*”), while stable elements are in yellow. The electrode is outlined in white. The boundary between the meninges and the hydrogel is denoted by white arrowheads. (b) Side projections at 7 dpi confirm that meningeal CX3CR1(+) cells (green) vascular dye (red) infiltrate the hydrogel (top) but not the silicone (bottom). (c) The velocity of cells migrating within the PEG/PEI gel are stable over 14 days. (d) The diameter of cells migrating within the PEG/PEI may increase after implantation (3–5 cells per time point, data presented as mean ± SEM).