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LC3B Tyr113 is highly conserved among eukaryotes and Y113C mutation is significantly present in cancer. (a) Histogram of the mutations on MAP1LC3B gene found in cancer tumors, taken from the COSMIC database. (b) Conservation of the C-terminal end of LC3B family with its homologs GABARAP and GABARAPL2. Tyr113 is marked with *. (c) Multiple sequence alignment of the C’-terminal end of LC3B with its orthologs. Color gradient represents level of conservation.
