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Schematic of the Study
(A) Glycoform heterogeneity in the monoclonal antibodies observed in the harvest of a fed-batch culture.
(B) Clonally propagated CHO-K1 cells with random integration of a monoclonal antibody gene were grown under two different processes, and time course analysis was performed on the transcriptome, metabolome, and mAb glycoform data to identify key bottlenecks.
