Figure 2.

Glycan Species from the mAbs Exhibit Similar Time Dynamics Despite Process Variation

(A) The two processes resulted in widely varying lactate profiles as well as cell growth and titer.

(B) Agalactosylated (G0) and high-mannose species increase over time, whereas terminal galactosylated and sialylated species decrease over time. Slight decrease in fucosylated species is also observed over time. A detailed classification of the glycan structures is provided in Data S2. Asterisks (*) represent p < 0.05 for two-tailed unpaired t tests comparing CC and HD samples from each day.