Sample sizes ranged from 6 to 4925, and the median sample size was 179. The highest percentage of studies (29.9%) had sample sizes in the range between 101 and 200; only 4.3% of studies in this range resulted in an ultimate draft clinical decision support summary. On the contrary, only 6.5% of analyzed studies had sample sizes greater than 1000 patients, and 20.0% of these resulted in a draft clinical decision support summary. Orange shading highlights the percentage of studies for each sample size group (i.e. 101–200, 201–300, etc.) that resulted in a clinical decision support summary.