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. 2018 Dec 21;11(1):20. doi: 10.3390/nu11010020

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Cell viability of SW480 colorectal cancer cells at days 1 and 3 with the GSC treatment (0, 1, 10, 100, and 500 μg/mL). The relative cell viability was compared to the control. The data are expressed as the mean ± standard error of the mean (SEM) and a significant difference is denoted as * (p < 0.05). (B) Representative SW480 cell images after the GSC treatment (0, 1, 10, 100 and 500 μg/mL). Blue represents the DAPI-stained cell nuclei and the propidium iodide-stained dead cells are red. (Scale bar = 500 μm). (C) Cell viability of LS513 (Kirsten rat sarcoma viral oncogene homolog (KRAS)^G12D), HCT116 (KRAS^G13D), HT-29 (KRAS^WT/BRAF^Mut), Caco-2 (KRAS^WT/BRAF^WT) and A549 (KRAS^WT/BRAF^WT) during day 3 with GSC (0, 1, 10, 100, and 500 μg/mL) and Cetuximab (30 μg/mL) treatment. The relative cell viability was compared with the control. (D) IC₅₀ values of SW480 (KRAS^G12V), LS513 (KRAS^G12D), HCT116 (KRAS^G13D), HT-29 (KRAS^WT/BRAF^Mut), Caco-2 (KRAS^WT/BRAF^WT) and A549 (KRAS^WT/BRAF^WT) cell lines at day 3 under GSC treatment. The data are expressed as the mean standard error of the mean (SEM) and a significant difference is denoted as * (p < 0.05) compared to control. GSC: Cordyceps militaris on germinated soybeans. DAPI, 4′,6-diamidino-2-phenylindole.

(A) Cell viability of SW480 colorectal cancer cells at days 1 and 3 with the GSC treatment (0, 1, 10, 100, and 500 μg/mL). The relative cell viability was compared to the control. The data are expressed as the mean ± standard error of the mean (SEM) and a significant difference is denoted as * (p < 0.05). (B) Representative SW480 cell images after the GSC treatment (0, 1, 10, 100 and 500 μg/mL). Blue represents the DAPI-stained cell nuclei and the propidium iodide-stained dead cells are red. (Scale bar = 500 μm). (C) Cell viability of LS513 (Kirsten rat sarcoma viral oncogene homolog (KRAS)^G12D), HCT116 (KRAS^G13D), HT-29 (KRAS^WT/BRAF^Mut), Caco-2 (KRAS^WT/BRAF^WT) and A549 (KRAS^WT/BRAF^WT) during day 3 with GSC (0, 1, 10, 100, and 500 μg/mL) and Cetuximab (30 μg/mL) treatment. The relative cell viability was compared with the control. (D) IC₅₀ values of SW480 (KRAS^G12V), LS513 (KRAS^G12D), HCT116 (KRAS^G13D), HT-29 (KRAS^WT/BRAF^Mut), Caco-2 (KRAS^WT/BRAF^WT) and A549 (KRAS^WT/BRAF^WT) cell lines at day 3 under GSC treatment. The data are expressed as the mean standard error of the mean (SEM) and a significant difference is denoted as * (p < 0.05) compared to control. GSC: Cordyceps militaris on germinated soybeans. DAPI, 4′,6-diamidino-2-phenylindole.