Table 3.
HR of mortality by categories of 25-hydroxyvitamin D (25(OH)D, nmol/L), and estimates by categories assuming linearity for observational and MR estimates.
| Model | <30 | 30−39.9 | 40−49.9 | 50−74.9 | 75−99.9 (Ref) |
100−150 | |
|---|---|---|---|---|---|---|---|
| Basic information | Median nmol/L | 21.8 | 35.7 | 45.4 | 59.9 | 81.3 | 108.1 |
| N | 1303 | 1230 | 2174 | 4882 | 824 | 88 | |
| Deaths, n | 574 | 485 | 869 | 1808 | 250 | 17 | |
| Person years | 10592 | 12452 | 26904 | 57820 | 8434 | 837 | |
| Death Rate * | 54.2 | 38.9 | 32.3 | 31.3 | 29.6 | 20.3 | |
| Observational estimate by categories | HR | 1.76 | 1.29 | 1.11 | 1.06 | 1.00 | 0.83 |
| 95% CI | 1.50−2.07 | 1.11−1.51 | 0.95−1.28 | 0.93−1.22 | 0.51−1.36 | ||
| Observational estimate by linearity at midpoint | HR | 1.71 | 1.51 | 1.38 | 1.21 | 1.00 | 0.79 |
| 95% CI | 1.51−1.94 | 1.37−1.66 | 1.28−1.49 | 1.16−1.27 | 0.74−0.83 | ||
| MR (G1) estimate by linearity at midpoint | HR | 2.26 | 1.87 | 1.64 | 1.34 | 1.00 | 0.69 |
| 95% CI | 0.52−10.96 | 0.60-6.26 | 0.67−4.24 | 0.79−2.36 | 0.34−1.55 | ||
| MR (G2) estimate by linearity at midpoint | HR | 2.45 | 1.99 | 1.72 | 1.38 | 1.00 | 0.67 |
| 95% CI | 0.52−12.98 | 0.61−7.13 | 0.68−4.70 | 0.79−2.51 | 0.32−1.34 |
Analysis was done using Cox proportional hazards ratio adjusting for age, sex, study, season of blood draw, BMI, smoking, diabetes mellitus, arterial hypertension, history of cardiovascular disease, and history of cancer. HR = Hazards ratio; MR = Mendelian randomization; Ref = Reference group. * Per 1000 person years.