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. 2018 Dec 28;11(1):17. doi: 10.3390/v11010017

Figure 4.

Figure 4

Disruption in the 5′UTR nt95–110:NS5B nt8528–8543 duplex reduces intracellular HCV RNA levels. (A) Huh-7.5 cells transfected with HCV genomic RNA (WT) or HCV genomic RNA containing mutations at 5′UTR nt 95–110 and NS5B nt 8528–8543 express NS5B antigen 24 h post-transfection. Scale bar = 50 µm. (B) Plots represent the average number of HCV RNA genome copies ± SE in 1 μg of cellular RNA at 48 h post-transfection. p-values ≤ 0.05 (*) or ≤ 0.01 (**) were determined by the Student’s t-test and represent four or more independent experiments.