Table 3.
Systematic overview table of results.
| N | T | FS | ASC | FS + ASC | |
|---|---|---|---|---|---|
| In vivo imaging for ASC detection on tendon | - | - | - | Detection of labeled-ASC until the 7th day | Detection of labeled-ASC until the 14th day |
| Cell migration assay | - | - | - | Presence of ASC on the 21st day | Presence of ASC on the 21st day |
| Macrophages identification | Presence of few macrophages | Presence of few macrophages | Presence of few macrophages | Presence of few macrophages carring PKH26 signal | Presence of few macrophages carring PKH26 signal |
| Genes expression analysis | Lower expression of Mmp2, Mmp9, Timp2, Gdf5, Scx and Tnmd; and higher expression of Tnf and Dcn in relation to T, FS, ASC and FS + ASC groups | Lower Tnmd expression in relation to ASC group | Lower Tnmd expression in relation to ASC group | Higher Tnmd expression in relation to T and FS groups | No differences between the treatments |
| Total collagen concentration (entire tendon) | Lower concentration in relation to ASC group | No differences between the treatments and N group | No differences between the treatments and N group | No differences between the treatments and higher concentration in relation to N group | No differences between the treatments and N group |
| Collagen I and Tnmd quantification (entire tendon) | Lower amount in relation to T, FS and FS+ASC groups | No differences between the treatments | No differences between the treatments | No differences between the treatments and N group | No differences between the treatments |
| Total number of fibroblasts in the TR | Higher number of cells in relation to T, FS, ASC and FS+ASC groups | No differences between the treatments | No differences between the treatments | No differences between the treatments | No differences between the treatments |
| Collagen fibers organization measurements | Higher birefringence in relation to T, FS, ASC and FS+ASC groups | Lower birefringence in relation to FS, ASC and FS+ASC groups | Higher birefringence in relation to T, ASC and FS+ASC groups | Higher birefringence in relation to T group | Higher birefringence in relation to T and ASC groups |
| Biomechanical properties of tendons | Maximum Load: no differences in relation to T, FS, ASC and FS+ASC groups; Cross-sectional area: lower value in relation to T, FS, ASC and FS+ASC groups; Maximum Displacement and Strain: no differences in relation to T, FS, ASC and FS+ASC groups; Maximum Stress: higher value in relation to T, FS, ASC and FS+ASC groups | Maximum Load: higher value in relation to ASC and FS+ASC groups; Cross-sectional area: no differences between the treatments; Maximum Displacement and Strain: no differences between the treatments; Maximum Stress: no differences between the treatments | Maximum Load: no differences between the treatments; Cross-sectional area: no differences between the treatments; Maximum Displacement and Strain: no differences between the treatments; Maximum Stress: no differences between the treatments | Maximum Load: lower value in relation to T group; Cross-sectional area: no differences between the treatments; Maximum Displacement and Strain: no differences between the treatments; Maximum Stress: no differences between the treatments | Maximum Load: lower value in relation to T group; Cross-sectional area: no differences between the treatments; Maximum Displacement and Strain: no differences between the treatments; Maximum Stress: no differences between the treatments |