Table 2.
Studies involving the use of electrospun fibers in delivery of proteins, DNA, RNA and human factors (partial listing).
| Drug(s) | Polymer(s) | Solvent Composition | Spraying Type |
|---|---|---|---|
| plasmid DNA (pDNA) | PEI-HA [62] | Coaxial | |
| siRNA | PCL [150]; PCLEEP [149] Chitosan/PLGA [169] |
2,2,2-Trifluoroethanol (TFE) [150]; RNase-free water [149]; Hexafluoro-2-isopropanol/water [169] | Single nozzle |
| Human glial cell-derived neurotrophic factor | PCL-co-PCLEEP [170] | Dichloromethane | Single nozzle |
| Human β-nerve growth factor | PCL-co-PCLEEP [148] | Dichloromethane | Single nozzle |
| Endothelial growth factor VEGF | PECCL [152] | - | Single nozzle |
| Bovine Serum Albumin (BSA) | PEO [171] | Deionized water | Single nozzle |
| Lysozyme | PLA [97] | Chloroform | Emulsion |
| Human-nerve growth factor (NGF) | Poly(L-lactide-co-caprolactone) [172] | Chloroform | Emulsion |
| DNA | PLA-PEG and PLGA [94] | DMF | Single nozzle |
| Growth factors (VEGF, PDGF) | Poly(urethane) [63] | Chloroform: ethanol (75:25) | Coaxial |
| Horseradish peroxidase | PVA/PCL [86] | - | Coaxial |