Figure 1.

Histological features of sporadic inclusion body myositis muscle. Histological characteristics in a quadriceps muscle biopsy from a male 73 years old patient diagnosed with sporadic inclusion body myositis. (a) Modified Gomori trichrome stain reveals several vacuoles in a muscle fibre (asterisk). (b) Congo red stain detected under fluorescent light visualizes a muscle fibre with inclusions containing β-amyloid (asterisk). (c) Immunostaining of the ubiquitin-binding scaffold protein and autophagy receptor p62/sequestosome1 (3’-Diaminobenzidine stain, brown) shows sarcoplasmic p62-immunoreactive aggregates in a muscle fibre (arrow). (d) Haematoxylin and eosin stain showing autoaggressive inflammatory cells targeting a nonnecrotic muscle fibre (arrow). Magnification ×785 before reduction.