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. 2019 Jan 8;9(1):16. doi: 10.3390/biom9010016

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Side-by-side comparison between MDA-MB-231 and MDA-MB-468 cells. Representative western blots (A) show the effect of metformin (50 μM and 2 mM) in 25 mM glucose and 5.5 mM glucose on the levels of pmTOR (S2448) and mTOR in MDA-MB-231 and MDA-MB-468 cells, (B) show the effect of metformin (50 μM and 2 mM) in zero glucose/glucose-starved condition on the levels of pmTOR (S2448) and mTOR in MDA-MB-231 and MDA-MB-468 cells, (C) show the effect of metformin (50 μM and 2 mM) in 25 mM glucose and 5.5 mM glucose on the levels of p4EBP1 (T37/46), 4EBP1, pS6 (S235/236), pS6 (S240/244), and S6 ribosomal protein in MDA-MB-231 and MDA-MB-468 cells, and (D) show the effect of metformin (50 μM and 2 mM) in zero glucose/glucose-starved condition on the levels of p4EBP1 (T37/46), 4EBP1, pS6 (S235/236), pS6 (S240/244), and S6 ribosomal protein in MDA-MB-231 and MDA-MB-468 cells. β-actin was used as the loading control.