Table 5.
Estimated association between early-treated congenital hypothyroidism and ADHD or related behaviors.
| Estimated associations between early-treated congenital hypothyroidism and ADHD or related behaviors | ||
|---|---|---|
| Exposure | Outcome (Time) | Estimate |
| Congenital hypothyroidism | ||
| Kooistra 200456 | MST Impulsivity (7.0-8.8 yrs) | F = 0.66, p = 0.42 |
| Tinelli 200314 | CBCL impaired attention (10 yrs) | t = 0.007, p > .05 |
| CBCL impaired attention (13 yrs) | t = 2.665, p < .01 | |
| Kooistra 200157 | GBCS Impaired task orientation (7.5, 9.5 yrs) | NS |
| Rovet 2001a53 | Impaired attention across tasks (12.6-15.2 yrs) | F = 4.22, p < .001 |
| CBCL attention problems (12.6–15.2 yrs) | p < .001 | |
| Rovet 2001b54 | CPT impaired sustained attention (7-12 yrs) | NS |
| Rovet 199955 | PI impaired attention (vigilance), memory (13 yrs) | Significant, stats NR |
| Kooistra 199658 | ↓ sCPT self-paced sustained attention (7-8.75 yrs) | F = 5.70, p = .02 |
| ↓ cCPT computer-paced sustained attention (7-8.75 yrs) | F = .02, p = .9 | |
| Higher TSH at diagnosis | ||
| Rovet 2001b54 | CPT impulsivity (7-12 yrs) | r = 0.295 |
| CPT inattention (7-12 yrs) | r = 0.519, p < .01 | |
| Lower T4 at diagnosis | ||
| Rovet 2001b54 | CPT impulsivity (7-12 yrs) | r = .577, p<.001 |
| Rovet 199955 | PI impaired memory and attention (13 yrs) | Significant, stats NR |
Abbreviations: ADHD = Attention Deficit Hyperactivity Disorder, CBCL = Child Behavior Checklist, CPT = Conners Continuous Performance Task, cCPT = Computer-Paced Continuous Performance Task, GBCS = Groningen Behavior Checklist School/Family Situation, mos = months, MST = Memory Search Task, NR = Not reported, NS = Not significant, PI = A battery of behavioral Psychometric Instruments, sCPT = Self-Paced Continuous Performance Task, TSH = Thyroid stimulating hormone, T4 = Thyroxin, yrs = years.