Skip to main content
. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Bone. 2018 Oct 17;120:125–136. doi: 10.1016/j.bone.2018.10.013

Fig. 8: Model of TNAP Function in Bone Progenitor Cells.

Fig. 8:

TNAP is an enzymatic generator of inorganic phosphate (Pi). Our data shows that TNAP stimulates Erk1/2 activity via both Pi dependent and independent pathways. Erk1/2 activity promotes cell cycle progression, cytokinesis and bone progenitor cell renewal, which we hypothesize helps to maintain cranial suture mesenchyme tissue between growing calvarials, promote bone growth and prevent craniosynostosis. Erk1/2 activity also feeds back to inhibit FGFR2 expression.