TABLE 3.
Comparisons of the Proportions of Women Who Are Positive for 9-Valent HPV Types, 4-Valent HPV Types, and the 5 HPV Types Included in the 9-Valent But Not the 4-Valent Vaccine Across the 4 Study Waves by Vaccination Status: Results of Unadjusted and Adjusted Logistic Regression Analyses
| Vaccination Status | Wave 1–4 | Wave 2–4 | Wave 3–4 | |||
|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | aOR (95% CI) | Unadjusted OR (95% CI) | aOR (95% CI) | Unadjusted OR (95% CI) | aOR (95% CI) | |
| 9-valent vaccine–type HPVa | ||||||
| All | 0.24 (0.17 to 0.34)b | 0.25 (0.18 to 0.35)b | 0.35 (0.25 to 0.49)b | 0.42 (0.30 to 0.58)b | 0.66 (0.46 to 0.94)b | 0.74 (0.52 to 1.05) |
| Vaccinated | 0.20 (0.14 to 0.29)b | 0.18 (0.12 to 0.26)b | 0.30 (0.20 to 0.46)b | 0.32 (0.21 to 0.49)b | 0.77 (0.50 to 1.19) | 0.77 (0.50 to 1.21) |
| Unvaccinated | 0.46 (0.26 to 0.84)b | 0.95 (0.56 to 1.62) | 0.66 (0.35 to 1.25) | 1.35 (0.75 to 2.43) | 0.68 (0.35 to 1.35) | 0.87 (0.47 to 1.61) |
| 4-valent vaccine–type HPVc | ||||||
| All | 0.12 (0.08 to 0.20)b | 0.18 (0.12 to 0.27)b | 0.36 (0.22 to 0.60)b | 0.61 (0.39 to 0.95)b | 0.66 (0.38 to 1.16) | 1.06 (0.64 to 1.75) |
| Vaccinated | 0.10 (0.06 to 0.17)b | 0.13 (0.08 to 0.22)b | 0.39 (0.20 to 0.75)b | 0.66 (0.36 to 1.20) | 1.15 (0.52 to 2.54) | 2.13 (0.97 to 4.69) |
| Unvaccinated | 0.26 (0.12 to 0.60)b | 0.50 (0.26 to 0.97)b | 0.55 (0.23 to 1.32) | 1.17 (0.56 to 2.46) | 0.55 (0.22 to 1.39) | 0.84 (0.39 to 1.79) |
| 5 HPV types in the 9-valent but not the 4-valent vaccined | ||||||
| All | 0.43 (0.29 to 0.63)b | 0.44 (0.30 to 0.64)b | 0.38 (0.26 to 0.55)b | 0.42 (0.29 to 0.60)b | 0.69 (0.46 to 1.04) | 0.68 (0.46 to 1.02) |
| Vaccinated | 0.37 (0.24 to 0.57)b | 0.26 (0.16 to 0.42)b | 0.30 (0.19 to 0.47)b | 0.22 (0.13 to 0.36)b | 0.68 (0.42 to 1.10) | 0.48 (0.28 to 0.82)b |
| Unvaccinated | 0.76 (0.39 to 1.49) | 1.90 (1.09 to 3.34)b | 0.77 (0.37 to 1.59) | 1.79 (0.96 to 3.33) | 0.93 (0.43 to 2.02) | 1.30 (0.68 to 2.48) |
CI, confidence interval; OR, odds ratio.
a
HPV-6, -11, -16, -18, -31, -33, -45, -52, and -58.
b
P < .05.
c
HPV-6, -11, -16, and -18.
d
HPV-31, -33, -45, -52, and -58.