Video 9. Host cell extrusion simulation ending in bacterial clearance (left), stable steady state (center), and uncontrolled growth (right).
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DOI: 10.7554/eLife.40032.031
Bacterial clearance is triggered when the number of bacteria in epithelium reaches zero. Uncontrolled growth is triggered when the number of bacteria in epithelium reaches 105. Stable steady state is triggered when the number of extruded bacteria reaches 2 × 105 before the number of bacteria in epithelium reaches 105. Extrusion radius equals 1, extrusion period equals 0.2, and replication rate equals 1. Effective diffusion coefficients are 1 (bacterial clearance), 3 (stable steady state), and 9 (uncontrolled growth ) respectively.