Skip to main content
. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Nature. 2018 Dec 5;564(7735):213–218. doi: 10.1038/s41586-018-0772-0

Extended Data Figure 8: Silencing dCA2 inputs to dLS by CNO application reduces PSP in dLS neurons evoked by photostimulation.

Extended Data Figure 8:

a1. Co-expression of iDREADD and ChR2 in CA2 PNs. a2. Left, Light-evoked PSP in dLS neuron before and after bath application of 5 μM CNO. Scale bars 1 mV and 100 ms. Right, Quantification of effect of CNO on peak PSP amplitude showing individual cells (black, 7 cells from 3 mice) and mean ± SEM (red). Two-sided Wilcoxon test, *P=0.02. b. Schematic (b1) and LS coronal section (b2) from an Amigo2-Cre mouse expressing iDREADD and mCitrine in CA2 PNs and implanted with a cannula in LS. Mouse was infused with 1 μl miniRuby through the cannula 15 min before sacrifice. Labelling shows mCitrine expression (green) and miniRuby (red). Scale bar 400 μm.