. Author manuscript; available in PMC: 2020 Feb 5.

Published in final edited form as: Structure. 2018 Dec 6;27(2):241–252.e3. doi: 10.1016/j.str.2018.10.017

Table 1.

Druggability of GluA3 NTD LL interface pockets.

LL Probe Cluster	ΔG_B probe binding	Affinity	Probe composition	charge
Site 1 (near R163 & R184)	−11.4	5.6 nM	2 IPRO, 1 IPAM, 5 ACTT	4e⁻
Site 2 (near M150)	−13.08	0.34 nM	5 IPRO, 2 ACAM, 1 BENZ	0