The Authors Reply:
We appreciate the comment by Watanabe1 regarding possible mechanisms that could be associated with ibuprofen-induced renal tubular acidosis. We reviewed the suggested articles and are in agreement that these articles do point to mechanisms of action for carbonic anhydrase inhibition. Watanabe adds to our article2 by providing valuable insight into possible mechanisms at play. We also opine that based off this information, it is possible that naproxen, indomethacin, phenylbutazone, and aspirin also could behave in a similar manner, as they too have a similar chemical structure with similar carboxylate moieties.3
References
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