INTRODUCTION –
Stroke is one of the most common causes of mortality and morbidity in the world. Change of lifestyle, overwhelming stress and strains in all spheres of life, dietary habits and over competitiveness with a sustained struggle for existence have significantly increased the risk of hypertension and eventually cerebro-vascular accidents.
Since long behavioral disorders have been noticed by various clinicians and investigators as one of the most relevant disabilities of stroke syndrome. Such behavioral manifestation was merely considered a reaction to a devastating morbidity. In view of psychological reaction to any stress, disease or disability, much emphasis was give to this aspect.
However, with the advent of recent advances of technology, various non-invasive techniques like computerized tomography, MRI, PET, autoradiography of brain, various radio isotopic methods for evaluation of regional cerebral blood flow etc. Have given us a better understanding of Neuro-physiology and Neuro-psycho-pharmacology, electrophysiology, regional cerebral blood flow and overall picture of central synaptic transmission. Concentrated efforts using aforesaid technique provided us with ample evidence in favor of biological substratum of psychiatric manifestations following a stroke syndrome. As a result, there has been a resurgence of interest in proper identification of various organic psychiatric disorders, their underlying mechanism, anatomical and clinical correlations and overall management using various pharmacological agents.
It’s a general consensus that psychiatric symptoms play a pivotal role in symptoms formation and the overall disability of stroke syndrome. Very often due to superimpose of psychiatric disorders, the overall disability due to stroke syndrome per-se get exaggerated than the real magnitude of illness. It is therefore imperative to identify associated psychiatric disorders following cerebro-vascular accident more effectively and a holistic bio-psychosocial approach should be directed to achieve better result.
Keeping all these in view the present study was envisaged with the following aims and objectives.
AIM – to study post stroke psychiatric manifestations.
OBJECTIVE –
To study the clinical picture and etiological factors of stroke syndrome.
To evaluate the magnitude of various psychiatric disorders following stroke
To study the clinical profile of psychiatric disorders following stroke syndrome.
To correlate clinical phenomenology of psychiatric disorders with various clinical variables including nature & site of lesion.
METHDOLOGY -
Study design – case control study
Study site- Department of psychiatry SSMC REWA
Study duration- 18 months
Study sample- 90
Inclusion criteria
Patent of stroke syndrome coming in psychiatric OPD, IPD, geriatric OPD with or without aberrant manifestation.
Patient of strokes in acute phage as well as within 6 month of stroke will be included in the study.
No age bar.
Either sex
Patient giving written informed consent
Exclusion criteria
severe medical emergencies
Unconsciousness and cognitive decline.
Past h/o neuropsychiatric disorders.
Mental retardation.
Lack of consent.
Tools
Psychiatric rating scales (MBPRS, HAM-D, HAM-ANXIETY, Yale’s mania rating scales), for psychosis, depression anxiety and mania respectively.
Those patients fulfilling specific diagnostic categorisation on the basis of ICD-10 DCR will be subjected to quantification of the disorders using authentic rating scale.
WHO- SCALE (Quality of life).
NIH STROKE SCALE.
PROCEDURE –
The study will commence following the approval from department of scientific committee and institutional ethical and scientific committee.
The patients will be hospitalized whenever indicated.
All the patients will be evaluated using semi structural proforma for socio-demographic and clinical variables.
Detailed general and systemic examinations will be recorded and special emphasis will be given to higher functions consisting neurological and mental status examinations.
Psychiatric diagnosis will be based on recent diagnostic criteria of ICD-10(DCR).
INVESTIGATION: Routine baseline as well as specific investigation as given in proforma (LFT, KFT, Blood sugar, s. cholesterol)as and when indicated.
NEUROIMAGING: CT/MRI will be done in each patient to determine the site of lesion and nature of stoke.
Fundus will be examined in all patients.
ECHO will be done whenever required.
The sample of the study will be comprising of 90 patients of stroke syndrome
Attending psychiatric OPD, IPD and geriatric OPD fulfilling selection criteria.
The final psychiatric evaluation and their respective diagnosis will be made only after a period of 3 weeks to avoid the confounding variable of acute emotional turmoil.
Assessment of pre and post stroke psychosocial variables will be done.
The opinion of medical consultation will be done whenever needed.
Statistical analysis
The results will be subjected to statistical analysis using student’s t-test (continuous variables) and chi-squared test (categorical variables) to achieve significant of various clinical variable(p=<0.05)
Result and discussion:
As study is going the analysis will be done using SPSS v21by appropriate statistical analysis.