Table 1. CXCR4 expression is an (A) IPI score, (B) ABC/GCB subclass, (C) CD20 expression, and (D) GCB-CC/CB subtype-independent prognostic marker for R-CHOP-treated DLBCL patients.
| A | na | no. | Simple | Multiple | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| CHOP | CXCR4 | 157 | 77 | 1.26 | 0.88-1.80 | 0.20 | - | - | - |
| IPI | |||||||||
| 0-1 | 62 | 16 | 1 | ||||||
| 2-3 | 82 | 50 | 3.10 | 1.76-5.44 | 8.79E-05 | - | - | - | |
| 4-5 | 13 | 11 | 6.45 | 2.98-13.95 | 2.18E-06 | - | - | - | |
| R-CHOP | CXCR4 | 164 | 43 | 1.77 | 1.04-3.02 | 0.036 | 1.77 | 1.04-3.00 | 0.035 |
| IPI | |||||||||
| 0-1 | 70 | 9 | 1 | 1 | |||||
| 2-3 | 73 | 22 | 2.58 | 1.19-5.61 | 0.017 | 2.69 | 1.24-5.85 | 0.013 | |
| 4-5 | 21 | 12 | 6.73 | 2.81-16.14 | 1.93E-05 | 6.65 | 2.78-15.93 | 2.12E-05 | |
| B | n | no. | Simple | Multiple | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| CHOP | CXCR4 | 181 | 93 | 1.35 | 0.96-1.89 | 0.080 | - | - | - |
| Subclass | |||||||||
| ABC | 74 | 49 | 1 | ||||||
| GCB | 76 | 28 | 0.42 | 0.26-0.66 | 0.00023 | - | - | - | |
| UC | 31 | 16 | 0.72 | 0.41-1.27 | 0.26 | - | - | - | |
| R-CHOP | CXCR4 | 233 | 60 | 1.72 | 1.11-2.66 | 0.014 | 1.54 | 1.01-2.32 | 0.042 |
| Subclass | |||||||||
| ABC | 93 | 39 | 1 | 1 | |||||
| GCB | 107 | 16 | 0.30 | 0.17-0.53 | 4.42E-05 | 0.32 | 0.18-0.57 | 0.00014 | |
| UC | 33 | 5 | 0.29 | 0.11-0.73 | 0.0084 | 0.28 | 0.11-0.72 | 0.0078 | |
| C | n | no. | Simple | Multiple | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| CHOP | Entire cohort | ||||||||
| CXCR4 | 181 | 93 | 1.35 | 0.96-1.89 | 0.080 | - | - | - | |
| CD20 | 181 | 93 | 0.88 | 0.72-1.06 | 0.18 | ||||
| GCB (CC+CB)b | |||||||||
| CXCR4 | 59 | 19 | 1.24 | 0.53-2.88 | 0.62 | - | - | - | |
| CD20 | 59 | 19 | 0.95 | 0.54-1.67 | 0.85 | - | - | - | |
| R-CHOP | Entire cohort | ||||||||
| CXCR4 | 233 | 60 | 1.72 | 1.11-2.66 | 0.014 | 1.71 | 1.12-2.62 | 0.014 | |
| CD20 | 233 | 60 | 0.77 | 0.65-0.91 | 0.0024 | 0.75 | 0.62-0.90 | 0.0022 | |
| GCB (CC+CB)b | |||||||||
| CXCR4 | 83 | 14 | 5.03 | 1.93-13.09 | 0.00093 | - | - | - | |
| CD20 | 83 | 14 | 0.86 | 0.49-1.50 | 0.59 | - | - | - | |
| D | nb | no. | Simple | Multiple | |||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||||
| CHOP | CXCR4 | 59 | 19 | 1.24 | 0.53-2.88 | 0.62 | - | - | - |
| Subtype | |||||||||
| GCB-CC | 33 | 6 | 1 | ||||||
| GCB-CB | 26 | 13 | 3.39 | 1.29-8.94 | 0.013 | - | - | - | |
| R-CHOP | CXCR4 | 83 | 14 | 5.03 | 1.93-13.09 | 0.00093 | 4.57 | 1.71-12.18 | 0.0024 |
| Subtype | |||||||||
| GCB-CC | 58 | 5 | 1 | 1 | |||||
| GCB-CB | 25 | 9 | 5.40 | 1.81-16.16 | 0.0026 | 4.49 | 1.48-13.67 | 0.0081 | |
Connection of CXCR4 (217028_at) expression level to 5-year OS, analyzed using simple and multiple Cox’s proportional hazards regression models.
a IPI score information was not available for all patients, thus cohort sizes are reduced in this setting
b The cohort is restricted to patients classified as GCB-CC or GCB-CB; n, number of samples; no., number of events; HR, hazard ratio; CI, confidence interval; UC, unclassified; -, value is not available since significant results at the 5% level were obtained for only one of the independent variables when performing simple Cox’s proportional hazards regression analysis.