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. Author manuscript; available in PMC: 2019 Feb 10.
Published in final edited form as: Biochemistry. 2018 Nov 6;57(46):6470–6478. doi: 10.1021/acs.biochem.8b00997

Figure 1.

Figure 1.

Structure and 2D IR spectra of Val17- and Ala25-hIAPP. (A) Structure of hIAPP fibrils derived from ssNMR.16 Spectra and diagonal intensity slices of (B) Val17 and (C) Ala25 fibrils. Spectra of Ala25 fibrils (D) diluted 1:3 with unlabeled hIAPP and (E) formed in 2.5% HFIP. The diagonal slices were fit with pseudo-Voigt functions. The isotope peaks fits are highlighted in red and blue, and the unlabeled peak fits are given in green. The fitting routine and parameters are given in the Supporting Information.