Table 3.
T-tests for comparison of metabolite factor levels between HIV cases and controls and historical uninfected CATHGEN means
| Factor # | Factor description | MSI level | HIV cases (n = 24) | HIV controls (n = 24) | Historical CATH- GEN uninfected cases (n = 2185) | Historical CATHGEN uninfected controls (n = 1591) | Matched paired t-test p-values (HIV cases vs. controls) |
|---|---|---|---|---|---|---|---|
| 1 | Medium chain acylcarnitines | 1 | − 0.15 (− 0.5, 0.1) | − 0.08 (− 0.4, 0.2) | − 0.02 | 0.03 | 0.048 |
| 2 | Long chain dicar- boxylacylcarni- tines | 1 | 0.15 (0, 0.4) | 0.01 (− 0.3, 0.3) | 0.05 | − 0.08 | 0.32 |
| 3 | Short chain dicar- boxylacylcarniti- nes (SCDA) | 1 | − 0.07 (− 0.2, 0.1) | 0.28 (− 0.5, 0.1) | 0.04 | − 0.05 | 0.08 |
| 4 | Long chain acyl- carnitines | 1 | 0.67 (− 0.5, 1.2) | 0.1 (− 0.2, 0.4) | 0.01 | − 0.01 | 0.66 |
| 5 | Ketone related | 1 | 0.96 (− 1.3, 0.7) | 0.95 (− 1.3, 0.6) | 0.003 | − 0.01 | 0.79 |
| 6 | Medium chain acylcarnitines | 1 | − 0.16 (− 0.9, 0.4) | 0.06 (− 0.5, 0.5) | 0.06 | − 0.07 | 0.23 |
| 7 | Branched chain amino acids | 1 | − 0.07 (− 1, 0.8) | − 0.1 (− 0.5, 1.1) | 0.05 | − 0.07 | 0.34 |
| 8 | Urea cycle amino acids | 1 | − 0.46 (− 1, 0.6) | − 0.26 (− 0.9, 0.4) | 0.03 | − 0.07 | 0.95 |
| 9 | Short chain acyl- carnitines | 1 | − 0.1 (− 0.5, 0.7) | 0.28 (− 0.6, 0.7) | 0.12 | − 0.17 | 0.65 |
| 10 | Miscellaneous metabolites | 1 | − 0.12 (− 0.8, 0.4) | 0.59 (− 0.9, 0.1) | 0.05 | − 0.04 | 0.22 |
| 11 | Miscellaneous metabolites | 1 | − 0.62 (− 1.3, 0) | − 0.66 (− 1.1, - 0.2) | − 0.02 | 0.06 | 0.71 |
| 12 | Glutamine/gluta- mate, valine | 1 | 0.75 (− 0.2, 1.4) | − 0.16 (− 0.6, 0.1) | 0.06 | − 0.08 | 0.003 |
| 13 | Non-esterified fatty acids | 1 | 0.36 (− 0.1, 0.7) | − 0.13 (− 0.6, 0.4) | 0.03 | − 0.005 | 0.11 |
| 14 | C22 | 1 | 0.21 (− 0.3, 0.6) | 0.41 (− 0.3, 1) | 0.01 | − 0.01 | 0.40 |
Factors with p-value ≤ 0.1 are bold