Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature

Protein Science, 27: 1219–1226. doi:10.1002/pro.2928

Equation 1 has been erroneously printed, and should read as follows:

$${\mathrm{f} = \mathrm{f}}_0\text{exp} \left(\mathrm{s}*\mathrm{n}\right)$$

whereby f is the fraction of an allele competing against wild‐type, f ₀ is the fraction of this allele at generation zero, s is its selection coefficient, and n is the number of generations.

Note that if s > 0, as n increases, f/f₀ increases exponentially; however, given a finite population size, this value will plateau at fixation (i.e., complete takeover of the competing allele). Similarly, if s < 0, wild‐type would be fixated.