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. 2019 Jan 24;9(3):691–707. doi: 10.7150/thno.31022

Figure 2.

Figure 2

Characterization of IR780-CSOSA micelles. (A) Synthetic route of IR780-CSOSA. (B) 1H NMR spectra of IR780, CSOSA and IR780-CSOSA. The characteristic peaks are pointed out and magnified (upper). (C) UV-vis spectra of IR780, CSOSA and IR780-CSOSA solution. (D) Photothermal effect of IR780-CSOSA and free IR780 under laser irradiation (808nm, 1W/cm2) for 5 min. (E) In vitro NIR-triggered drug release profiles. IR780-CSOSA/DOX and CSOSA/DOX solutions after incubated in pH 6.8 PBS for 4 h were irradiated with or without laser (808 nm, 1 W/cm2) for 3 min. (n = 3). (F) Size changes of IR780-CSOSA and IR780-CSOSA/DOX micelles at different temperatures by Zetasizer. (G) Transmission electron microscope (TEM) images of IR780-CSOSA and IR780-CSOSA/DOX micelles at 37 °C and 56 °C.