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In vivo fluorescent and photothermal imaging. (A) In vivo NIR fluorescence imaging in MCF-7 or 4T1 or H22 tumor models of IR780-CSOSA micelles after intravenous injection for 4, 12, 24 and 48 h., respectively. (B) Infrared thermal images of MCF-7 tumor-bearing mice intravenously injected with saline, CSOSA/DOX, IR780-CSOSA/DOX during 5 min of laser irradiation (808 nm, 0.5 W/cm2), respectively.
