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. 2019 Jan 29;8:e44036. doi: 10.7554/eLife.44036

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© 2019, Sen et al

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Figure 6. — (A–C) Dam:Hb binds within neuroblast-specific open chromatin. (A) Dam signal (open chromatin) in NB 5–6 (blue lines) and NB 7–4 (green lines) at loci where Dam:Hb binding is enriched in NB5-6 over NB7-4. Note that the chromatin is more open in NB5-6 than in NB7-4 at these loci. (B) Dam signal (open chromatin) in NB 7–4 (green lines) and NB 5–6 (blue lines) at loci where Dam:Hb binding is enriched in NB7-4 over NB5-6. Note that the chromatin is more open in NB7-4 than in NB5-6 at these loci. (C) Dam signal (open chromatin) at loci similarly occupied by Hb in both NB5-6 and NB7-4 lineages. (D) The top five Dam:Hb enriched loci in NB5-6 are in regions of NB5-6 open chromatin (blue tracks); however, in NB7-4 these loci are not in open chromatin (Dam; green tracks), and are not bound by Dam:Hb. Rows from top to bottom: genomic locus, Dam:Hb enrichment in NB5-6, Dam only enrichment in two replicates in NB5-6, Dam:Hb enrichment in NB7-4, and Dam only enrichment in two replicates in NB7-4. Data range for IP3K1, rut, pbl is 0–109; data range for CG13131 and mspo is 0–15. (E) The top five Dam:Hb enriched loci in NB7-4 are in regions of open chromatin in NB7-4 (green tracks); however, in NB5-6 these loci are not in open chromatin (Dam; blue tracks) and are not bound by Dam:Hb. Rows from top to bottom: genomic locus, Dam:Hb enrichment in NB5-6, Dam only enrichment in two replicates in NB5-6, Dam:Hb enrichment in NB7-4, and Dam only enrichment in two replicates in NB7-4. Data range for sqz, InR and en is 0–35; data range for lov and H15 is 0–20.

Figure 6—figure supplement 1. — (A–C) Dam:Hb binds within neuroblast-specific open chromatin. (A) Dam signal (open chromatin) in NB 5–6 (blue lines) and NB 7–4 (green lines) at loci where Dam:Hb binding is enriched in NB5-6 over NB7-4. Note that the chromatin is more open in NB5-6 than in NB7-4 at these loci. (B) Dam signal (open chromatin) in NB 7–4 (green lines) and NB 5–6 (blue lines) at loci where Dam:Hb binding is enriched in NB7-4 over NB5-6. Note that the chromatin is more open in NB7-4 than in NB5-6 at these loci. (C) Dam signal (open chromatin) at loci similarly occupied by Hb in both NB5-6 and NB7-4 lineages. (D) The top five Dam:Hb enriched loci in NB5-6 are in regions of NB5-6 open chromatin (blue tracks); however, in NB7-4 these loci are not in open chromatin (Dam; green tracks), and are not bound by Dam:Hb. Rows from top to bottom: genomic locus, Dam:Hb enrichment in NB5-6, Dam only enrichment in two replicates in NB5-6, Dam:Hb enrichment in NB7-4, and Dam only enrichment in two replicates in NB7-4. Data range for IP3K1, rut, pbl is 0–109; data range for CG13131 and mspo is 0–15. (E) The top five Dam:Hb enriched loci in NB7-4 are in regions of open chromatin in NB7-4 (green tracks); however, in NB5-6 these loci are not in open chromatin (Dam; blue tracks) and are not bound by Dam:Hb. Rows from top to bottom: genomic locus, Dam:Hb enrichment in NB5-6, Dam only enrichment in two replicates in NB5-6, Dam:Hb enrichment in NB7-4, and Dam only enrichment in two replicates in NB7-4. Data range for sqz, InR and en is 0–35; data range for lov and H15 is 0–20.