Table 2.

Furosemide stress test (FST) receiver operation characteristics, sensitivity and specificity for development of DGF at 2 and 6 h. The primary outcome was delayed graft function (DGF) the requirement for dialysis (A) during the first 7 days of transplantation (B) during the first 7 days of transplantation excluding those dialyzed during the first 24 h

	ROC	Sensitivity	Specificity	p-Value
(A) DGF during the first 7 days post transplantation
(A) Total urine output over 2 h
<50	0.73	67.0	76.4	0.06
<100	0.78	73.4	77.4	<0.001
<150	0.79	82.0	69.0	<0.001
<200	0.76	72.3	69.8	<0.001
<300	0.79	76.0	66.0	<0.001
(B) Total urine output over 6 h
<300	0.80	71.3	80.2	<0.001
<400	0.83	82.0	75.4	<0.001
<500	0.84	81.0	75.4	<0.001
<600	0.85	83.0	74.0	<0.001
<700	0.84	76.0	76.4	<0.001
<800	0.83	70.2	77.3	<0.001
Pre-transplant oliguria	0.62	41.5	81.9	<0.05
(B) DGF during the first 7 days post transplantation excluding those dialyzed during the first 24 h
(A) Total urine output (mL) over 2 h
<50	0.73	61.5	79.2	<0.001
<100	0.78	74.4	70.8	<0.001
<150	0.79	76.9	69.0	<0.001
<200	0.76	74.4	67.0	<0.001
<300	0.79	76.9	67.0	<0.001
(B) Total urine output (mL) over 6 h
<300	0.80	71.8	78.3	<0.001
<400	0.84	84.6	75.5	<0.001
<500	0.86	84.6	76.4	<0.001
<600	0.85	87.2	74.5	<0.001
<700	0.85	79.5	76.4	<0.001
<800	0.84	76.9	77.4	<0.001

Unadjusted and adjusted area under the receiver operator curves (AUC) were calculated for the prediction of DGF at all UO values at 2h and 6 h. Adjusted AUC that predicted DGF for different values of UO at 2 and 6h were generated based on the result of the multiple logistical regression (MLR) analysis for each UO value. Known predictors of DGF used in the MLR analysis were donor age, donor race, donor terminal creatinine, cold ischemic time, recipient weight and baseline urinary flow rate (UFR) (defined as non-oliguria UO > 400 mL/24 h versus oliguria UO < 400 mL/24 h). Hour 2 is the sum of the first 2 h after the furosemide stress test (FST) and is the sum of the urine output from the first and second hour after the FST. Hour 6 is the first 6 h after the FST and is the sum of the urine output from the first, second, third, fourth, fifth, and sixth hour after the FST. Adjusted for terminal creatinine, donor age, donor race, recipient baseline UFR (oliguria versus no oliguria), cold ischemic time, Recipient weight. UFR-raw: pre-furosemide baseline UFR; UFR-ABW: pre-furosemide baseline UFR adjusted for actual body weight. ROC AUC: receiver-operating characteristic AUC. Oliguria is defined as <400 mL/UO in 24 h.