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Permeability and solubility of compounds selected by their in vitro microsomal stability.
| Compd. | Permeability [nm/s] |
Retention | Solubility [μM] |
|---|---|---|---|
| 2 | 23.8 | 47% | 15.5 |
| 21 | 3.4 | 61% | nd |
| 22 | 13.2 | 34% | nd |
| 23 | 0.3 | 30% | 58.7 |
| 28 | 72.9 | 17% | 16.0 |
| 31 | 21.1 | 24% | 47.5 |
| 52 | 34.3 | 40% | nd |
| 72 | 1.98 | 45% | 36.7 |
