Figure 1.

Study Design. (A) Map of Peru depicting participant recruitment locations at high-altitude, Cerro de Pasco (4,338m), and low-altitude, Lima (0m); (B) LINE-1 DNA methylation was determined in 572 Peruvian Quechua with different exposures to high-altitude hypoxia over their lifetime. High-altitude Quechua (HAQ) were born, raised, and reside in or near Cerro de Pasco, Peru. Migrant Quechua (MQ) were born and raised at high altitude (>2,500 m), but moved to low-altitude Lima (0m) during the lifetime. Low-altitude Quechua (LAQ) were born, raised, and reside at sea-level in Lima.