Table 3.

Significant one-carbon metabolism SNPs.

Gene	SNP	Model	MAF	Minor allele	Function	β (95% CI)	p-value
FOLH1	rs202676	Additive	0.39	G	Loss of stop	0.21 (0.04, 0.38)	0.018
GLDC	rs10975681	Additive	0.30	C	Intronic	−0.17 (−0.33, −0.01)	0.042
MTHFD1	rs2236225	Additive	0.34	A	Missense	0.22 (0.05, 0.40)	0.014
TYMS	rs502396	Additive	0.40	T	Intronic	0.23 (0.06, 0.40)	0.008

All models were adjusted for the altitude of birth, sex, age, BMI, and PC1