Table 1.

Excess risk of IHD events in survivors of mediastinal malignancies after treatment with radiation therapy

	Darby et al, 20135	van Nimwegen et al, 20164
	Breast cancer survivors treated with RT	HL survivors treated with RT
N	2168	2617
Study period	1958–2001	1965–2013
Primary endpoint	Major IHD event	Major IHD event

Mean heart dose, GY, Darbyet al5	Risk ratio for IHD events		Mean heart dose, GY, van Nimwegen et al4
<2.0	1.10	1.14	1–5
2–4	1.30	2.14	5–15
5–9	1.40	2.76	15–19
≥10	2.16	2.79	20–24
		3.21	25–34
		2.54	35–45
Total excess risk per Gy
7.4% (95% CI 2.9 to 14.5)		7.4% (95% CI 3.0 to 15.8)

HL, Hodgkin’s lymphoma; IHD, ischaemic heart disease; RT, radiotherapy.