Table 1.
Pharmacokinetic parameters of eight constituents in rats plasma after oral administration of ginger extract at a dose of 400 mg/kg (n = 10, mean ± SD).
| Analytes | AUC(0–t) (μg/L·h) | t1/2 (h) | Tmax (h) | Cmax (μg/L) |
|---|---|---|---|---|
| 6-gingerol | 691.5 ± 80.7 | 2.6 ± 0.7 | 0.9 ± 0.2 | 255.4 ± 44.7 |
| 6-shogaol | 545.3 ± 95.7 | 3.9 ± 1.2 | 0.7 ± 0.3 | 214.4 ± 40.7 |
| 8-gingerol | 579.4 ± 79.4 | 2.7 ± 0.3 | 1.1 ± 0.2 | 156.0 ± 23.5 |
| 8-shogaol | 171.3 ± 25.9 | 3.0 ± 1.2 | 0.9 ± 0.2 | 46.5 ± 9.7 |
| 10-gingerol | 259.1 ± 46.0 | 2.7 ± 0.4 | 1.5 ± 0.3 | 92.8 ± 11.3 |
| 10-shogaol | 101.3 ± 24.6 | 2.5 ± 2.4 | 1.4 ± 0.4 | 32.5 ± 6.2 |
| Zingerone | 641.0 ± 85.3 | 2.2 ± 0.4 | 0.7 ± 0.3 | 174.8 ± 23.0 |
| 6-isodehydrogingenone | 63.7 ± 9.7 | 1.0 ± 1.1 | 1.1 ± 0.2 | 24.4 ± 8.1 |