Figure 4.

The chemical structures of compounds selected for activity evaluation (a). The amyloid fibril disrupting capacity of compounds (10 μM) when incubated with V30M-TTR tetramer (b) and WT-TTR tetramer (c) for 24 h, then quantified with ThT assay. Data sets were analyzed by Tukey-Kramer multiple comparison test. * p < 0.05; ** p < 0.01; *** p < 0.001 as compared with control (respective TTR treated with DMSO in each experiment); All experiments were performed in triplicate (means ± SEM, n = 3).