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. 2019 Jan 22;24(3):378. doi: 10.3390/molecules24030378

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The structures of antivirulence compounds that have been discovered using SBDD techniques. IC₅₀, half-maximal inhibitory concentration. 1, LasR quorum sensing inhibitor N-(heptylsulfanylacetyl)-L-homoserine lactone [54]; 2, bifunctional pilicide/curlicide FN075 [61]; 3, AgrA transcription factor inhibitor diflunisal [81]; 4, Type 3 secretion system (T3SS) inhibitor 7146 [74]; 5, DsbA thiol disulfide oxidoreductase inhibitor [85]; 6, acetyl homoserine lactone (AHL) synthase quorum sensing inhibitor trans cinnamaldehyde [89].