Skip to main content
Frontiers in Physiology logoLink to Frontiers in Physiology
. 2019 Feb 15;10:102. doi: 10.3389/fphys.2019.00102

Corrigendum: Chorioamnionitis Is a Risk Factor for Intraventricular Hemorrhage in Preterm Infants: A Systematic Review and Meta-Analysis

Eduardo Villamor-Martinez 1, Monica Fumagalli 2, Owais Mohammed Rahim 1, Sofia Passera 2, Giacomo Cavallaro 2, Pieter Degraeuwe 1, Fabio Mosca 2, Eduardo Villamor 1,*
PMCID: PMC6385522  PMID: 30828303

In the original article, there was a mistake in Supplementary Table 1 and Supplementary Table 2 as published. The study by Vaihinger et al. was incorrectly given “8” points on the Newcastle Ottawa Scale instead of “9”. The corrected Supplementary Table 1 and Supplementary Table 2 appears below.

Table 1.

Synoptic table of characteristics of all included studies.

First author, year Location (s) Cohort/ case-controla Perspectivea Prosp/Retro Total infants (centers) Mean BW (g) Mean GA (wks) Male (%) ACS (%) CA categoryb Incidence of CA (%) Definition of CAc Incidence of all IVH (%) Incidence of severe IVH (%) Definition of IVHd NO-S Quality score
Aden, 2013 Sweden, Finland, USA Ca-co IVH Prosp 612 (27) 844 26,2 59 100 CCA 23 NoDes 37 NA 6
Ahn, 2012 Seoul, Korea Cohort CA Prosp 257 (1) 1536 30,6 60 HCA 35 Ref 2 Ref 8
Alexander, 1998 Dallas, USA Cohort CA Prosp 1367 (1) 1138 28,9 CCA 7 Des 12 Ref 7
Arayici, 2004 Ankara, Turkey Cohort CA Retro 281 (1) 1173 28,9 55 71 HCA 52 Des 10 Ref 7
Austeng, 2010 Sweden Cohort CA Prosp 468 (7) 767 24,9 55 71 CCA 17 NoDes 14 Ref 8
Babnik, 2006 Ljubljana, Slovenia Cohort CA-IVH Prosp 125 (1) 1019 27 54 53 HCA & F 39 Des 41 Ref 7
Barrera-Reyes, 2011 Mexico, Mexico Cohort CA Prosp 104 (1) 1071 30,0 52 CCA 22 Ref 29 NA 6
Baumert, 2008 Katowice, Poland Ca-co IVH Prosp 2675 (1) 3351 38,3 51 CCA 4 NoDes 15 Ref 7
Been, 2009 Rotterdam, Nehterlands Cohort CA Prosp 301 (1) 1143 29,1 51 70 HCA 40 Des 15 4 NA 7
Bermick, 2016 Michigan, USA Cohort IVH Retro 216 764 25,5 51 81 HCA 41 NoDes 56 NA Ref 8
Bordigato, 2010 Padova, Italy Cohort CA Prosp 29 (1) 805 26,7 59 76 HCA 48 Ref 27 3 NA 7
Botet, 2010 Spain Ca-co CA Prosp 328 (12) 1057 28,2 54 HCA 50 Ref 27 12 NA 8
Bry, 2015 Gothenburg, Sweden Cohort CA Prosp 24 (1) 777 25,9 50 100 HCA 67 Ref 17 NA 6
Dalton, 2015 Michigan, USA Cohort IVH Retro 216 (1) 764 25,5 51 81 HCA 41 NoDes 56 Ref 6
Dempsey, 2005 Montreal, Canada Cohort CA Retro 330 (1) 987 27,0 63 HCA 39 Des 10 Ref 7
Dexter, 2000 Rhode Island, USA Cohort CA Prosp 275 (1) 904 26,5 53 22.3 HCA 57 Des 32 10 NA 6
Ecevit, 2014 Ankara, Turkey Cohort CA Retro 36 (1) 1524 29,7 59 HCA 58 Des 19 NA 6
Elimian, 2000 New York, USA Cohort CA Prosp 1260 (1) 1183 29.0 42 HCA 42 Ref 27 12 Ref 9
Erdemir, 2013 Izkir, Turkey Cohort CA Prosp 57 (1) 1675 30,8 46 65 HCA and/or CCA 21 Des 12 NA 6
Fung, 2003 Clayton, Australia Cohort CA Prosp 62 (1) 794 26,2 50 83 HCA and/or CCA 25 Des 24 NA 6
Gagliardi, 2014 Italian Neonatal Network Cohort CA Retro 3606 (82) 938 27,4 50 84 CCA 42 NoDes 11 Ref 9
Garcia-Munoz Rodrigo, 2014 Spanish Network Cohort CA Prosp 8330 (53) 1086 28,5 52 87 CCA 18 Des 10 NA 9
Gawade, 2013 Springfield, USA Cohort IVH Retro 78 (1) 980 26,8 59 85 CCA 15 Nodes 44 12 Ref 6
Gonzalez-Luis, 2002 Barcelona, Spain Ca-co CA Retro 135 (1) 1147 28,9 CCA 33 Des 20 7 NA 7
Gray, 1997 Brisbane, Australia Cohort IVH Retro 158 (1) 955 27,0 57 HCA and/or CCA 10 Des 25 8 NA 7
Hendson, 2011 Edmonton, Canada Cohort CA Prosp 617 (1) 930 26,9 48 83 HCA 48 Des 16 Ref 7
Hitti, 2001 Seattle, USA Cohort CA Prosp 140 (2) 1699 29,3 51 Microbiol 17 Des 14 6 Ref 7
Holcroft, 2003 Baltimore, USA Ca-Co CA Retro 213 (1) 1045 28,3 CCA 21 Des 36 NA 5
Kallankari, 2010 Oulu, Finland Cohort IVH Prosp 163 (1) 92,2 86 HCA 39 Ref 14 Ref 7
Kaulkola,2006 Oulu, Finland Cohort IVH Prosp 51 (1) 772 27 41 90 HCAA 49 Ref 22 Ref 7
Kidokoro New Zealand, Australia, USA Cohort IVH Prosp 325 (3) 959 27,5 47 86 CCA 22 Des 19 4 Ref 8
Kim, 2015 Seoul, Korea Cohort CA Retro 235 (1) 1104 29,2 50 81 HCA & F 38 Ref 6 NA 7
Kirchner, 2007 Vienna, Austria Cohort CA Retro 44 (1) 27,9 53 93 Microbiol 34 NoDes 9 Ref 7
Klebermans-Schrehof Vienna, Austria Cohort IVH Retro 471 (1) 996 27,4 53 93 HCA and/or CCA 38 NoDes 32 Ref 7
Kosuge, 2000 Minamikawac hi-machi, Japan Cohort CA Retro 81 (1) 1181 28,1 68 17 HCA 54 Ref 11 NA 6
Lau, 2005 Vancouver, Canada Cohort CA Prosp 1296 (1) 2068 33,2 55 47 HCA & F 31 Ref 5 Ref 7
Lee Hyun Ju, 2011 Seoul, Korea Cohort CA Retro 147 (2) 791 27 55 67 HCA 48 Ref 40 Ref 7
Lee Ju Young, 2010 Seoul, Korea Ca-Co IVH Retro 177 (2) 954 27,5 53 HCA 45 NoDes 22 Ref 8
Lim, 2011 Taiwan Ca-Co IVH Retro 72 (1) 768 24,7 64 CCA 13 Des 50 Ref 9
Linder, 2003 Israel Ca-Co IVH Retro 105 (1) 826 25,4 58 73 CCA 24 Des 34 Ref 9
Liu, 2014 Changhai, China Cohort CA Prosp 95 (1) 1706 31,7 58 89 HCA 52 Ref 43 8 Ref 7
Logan, 2013 USA Cohort IVH Retro 921 (14) 51 90 HCA 36 Des 6 NA 7
Lu, 2016 Jiangsu, China Ca-Co IVH Retro 137 (1) 1205 31,9 58 50 HCA & CCA 44 Des 24 Ref 7
Mehta, 2006 New Brunswick, USA Cohort CA-IVH Retro 164 (1) HCA 39 Ref 37 NA 7
Mestan, 2010 Boston, USA Cohort CA Prosp 256 (1) 1437 30,3 48 77 HCA 37 Ref 4 Ref 7
Miyazaki, 2016 Network database, Japan Cohort CA Retro 4078 (54) 973 27,6 49 41 HCA 30 Ref 15 Ref 9
Morales, 1987 Orlando, USA Ca-Co Ca Prosp 86 (1) 1178 29,2 HCA & CCA 50 Des 86 28 Ref 7
Mu, 2008 Taipei, Taiwan Cohort CA Prosp 119 (1) 1108 28,6 54 45 HCA 54 Ref 22 17 Ref 8
Nasef, 2013 Toronto, Canada Cohort CA Retro 274 (1) 952 27 55 85 HCA & CCA 47 Ref 23 1 Ref 7
Ogunyemi, 2003 New jersey, USA Cohort CA Retro 774 (1) 1313 29,4 53 HCA 33 Ref 39 5 NA 7
Oh, 2015 Seoul, Korea Cohort CA Retro 175 (1) 765 27,1 55 60 HCA 25 Ref NA Ref 9
Oh, 2018 Seoul, Korea Cohort IVH Retro 207 1269 29.7 48 75 HCA 44 Ref 7* NA Ref 9
Ohyama, 2002 Yokohama, Japan Cohort CA Retro 143 (1) 1162 27,8 HCA & F 63 Ref 9 NA 6
Osmanagaoglu, 2005 Trabzon, Turkey Cohort CA Retro 254 (1) 1828 32 56 65 CCA 12 Ref 6 NA 7
Pappas, 2014 USA Cohort CA Prosp 1918 (16) 24,4 51 75 HCA 55 Ref 29 NA 6
Perrone, 2012 Siena, Italy Cohort CA Prosp 92 (1) 998 26,3 HCA 49 Ref 48 Ref 7
Polam, 2005 New Brunswick, USA Cohort CA Prosp 177 (1) 955 26,5 53 74 HCA 58 Des 26 7 NA 6
Poralla, 2012 Bonn, Germany Cohort IVH Retro 132 (1) 714 25,5 50 87 CCA 39 Des 44 NA 6
Richardson, 2006 London Ontario, Canada Cohort CA Retro 660 (1) 1602 30,1 55 HCA 44 Des 22 NA 6
Rocha, 2006 & Rocha, 2007 Porto, Portugal Cohort CA Retro 452 (3) 1504 29,5 52 65 HCA 28 Ref 18 9 Ref 9
Rodríguez-Trujillo, 2016 Barcelona, Spain Cohort CA Prosp 165 (1) 1721 30,2 HCA 67 NoDes 10 NA 7
Rong, 2012 Wuhan, China Ca-co IVH Retro 232 (3) 1566 30,7 73 41 CCA 19 NoDes 34 NA 8
Ryckman, 2011 Iowa, USA Cohort IVH Prosp 219 58 CCA 15 NoDes 22 Ref 6
Salas, 2013 Alabama, USA Cohort CA Retro 347 (1) 829 26,1 50 62 HCA 43 Ref 17 Ref 7
Sarkar, 2005 New York, USA Cohort CA-IVH Prosp 62 (1) 884 62,2 45 90 HCA 47 Ref 15 7 Ref 7
Sato, 2011 Yokohama, Japan Cohort CA Retro 302 (1) 938,4 26,3 52 62 HCA 52 Ref 27 NA 7
Seliga-Siwecka, 2013 Warsaw, Poland Cohort CA Prosp 383 (1) 1338 29,2 56 84 HCA 37 Ref 45 Ref 9
Shankaran, 2014 USA and Sweden Ca-co IVH Prosp 1111 (24) 817 26,0 56 53 CCA 29 NoDes 52 Ref 8
Smit, 2015 Veldhoven, Netherlands Cohort CA Retro 300 (1) 1303 29,4 54 92 HCA & F 45 Ref 4 NA 7
Soraisham, 2009 Canadian Neonatal Network Cohort CA Prosp 3094 (24) 1320 28,9 53 79 CCA 15 Des 14 Ref 9
Soraisham, 2013 Regional NICU Southern Alberta, Canada Cohort CA Retro 384 (1) 885 26,3 51 86 HCA 51 Des 21 7 Ref 6
Suarez, 2001 Chicago, USA Ca-co IVH Retro 280 (1) 1328 29,6 56 CCA 19 Des 20 Ref 7
Suppiej, 2009 Padova, Italy Cohort CA Prosp 104 (1) 1078 28,5 46 87 HCA 39 Ref 13 Ref 6
Trevisanuto, 2010 Padua, Italy Ca-co CA Prosp 142 (1) 1075 27,8 55 89 HCA 50 Ref 4 Ref 8
Tsiartas, 2013 Králove, Czech Republic Cohort CA Retro 231 (1) 1975 33,0 56 HCA & F 61 Ref 20 1 Ref 7
Vaihinger, 2013 Buenos Aires, Argentina Ca-co IVH Retro 198 (1) 1072 28,0 53 66 CCA 24 NoDes 25 Ref 9
van Vliet, 2012 Amsterdam, Netherlands Cohort CA Prosp 72 (1) 1110 29,0 51 82 HCA 29 Ref 29 NA 6
Vergani, 2004 Monza, Italy Cohort IVH Retro 653 (1) 1335 30,1 50 50 CCA 11 Des 7 Ref 7
Watterberg, 1999 Pennsylvania, USA Cohort CA Prosp 40 (2) 751 25,3 38 85 HCA 55 NoDes 38 8 Na 7
Wirbelauer, 2011 Wuerzburg, Germany Cohort CA Prosp 71 (1) 871 27,9 52 94 HCA & F 24 Ref 9 Ref 7
Xu, 2012 Hangzhou, China Cohort IVH Prosp 88 (1) 1540 31,8 53 HCA and/or CCA 47 NoDes 25 8 Ref 7
Yamada, 2015 Miyazaki, Japan Cohort CA Prosp 212 (1) 25 HCA 65 Ref 20 NA 7
Yanowitz, 2006 Pittsburgh, USA Cohort CA Prosp 49 (1) 1273 28,7 61 HCA 49 Ref 57 2 Ref 7
Yoon, 1995 Seoul, Korea Cohort CA Prosp 50 (1) 1852 31,8 HCA 58 Ref 30 NA 7
Zanardo, 2008 Padua, Italy Cohort CA-IVH Prosp 287 (1) 1146 29,3 48 80 HCA 24 Ref 12 1 Ref 7

CA, chorioamnionitis; IVH, intraventricular hemorrhage; NOS, Newcastle-Ottawa Scale; ACS, antenatal corticosteroids.

a

Abbreviations for study design: Ca-Co, case-control study; Perspective, CA, study analyzed IVH as outcome of chorioamnionitis; Perspective, IVH, study analyzed chorioamnionitis as risk factor for IVH; Perspective, CA-IVH, study analyzed the association between chorioamnionitis and IVH as primary outcome. Prosp, prospective; Retro, retrospective;

b

Chorioamnionitis category: CCA, clinical chorioamnionitis; HCA, histological chorioamnionitis; HCA & F, histological chorioamnionitis with funisitis mentioned separately. HCA and/or CCA, chorioamnionitis defined as positive when infants had histological or clinical chorioamnionitis; Microbiol, microbiological chorioamnionitis.

c

Definition of chorioamnionitis: NoDes, no description; Des, clinical or histological description; Ref, defined according to cited article.

d

Definition of ROP: ICROP, International Classification of Retinopathy of Prematurity; Ref, defined according to cited article; Treat, laser treatment of ROP; NA, no diagnostic criteria mentioned.

Table 2.

Newcastle-Ottawa Quality assessment of included studies.

First author, year Perspective Select. Comp. Outc. Total Reason for downgrade
Aden, 2013 IVH 4 0 2 6 No adjustment
Ahn, 2013 CA 4 1 3 8 Only adjusted for 1 factor
Alexander, 1998 CA 4 0 3 7 No adjustment
Arayici, 2004 CA 4 0 3 7 No adjustment
Austeng, 2010 CA 3 2 3 8 No CA definition
Babnik, 2006 CA-IVH 4 0 3 7 No adjustment
Barrera-Reyes, 2011 CA 4 0 2 6 No adjustment
Baumert, 2008 IVH 4 0 3 7 No adjustment
Been, 2009 CA 4 0 3 7 No adjustment
Bermick, 2016 IVH 3 2 3 8 No CA definition
Bordigato, 2010 CA 4 0 3 7 No adjustment
Botet, 2010 CA 4 1 3 8 Only adjusted for 1 factor
Bry, 2015 CA 4 0 2 6 No adjustment
Dalton, 2015 IVH 3 0 3 6 No CA definition
Dempsey, 2005 CA 4 0 3 7 No adjustment
Dexter, 2000 CA 4 0 2 6 Loss to follow up, no adjustment
Ecevit, 2014 CA 4 0 2 6 No IVH definition, no adjustment
Elimian, 2000 CA 4 2 3 9
Erdemir, 2013 CA 4 0 2 6 No IVH definition, no adjustment
Fung, 2003 CA 4 0 2 6 No IVH definition, no adjustment
Gagliardi, 2014 CA 4 2 3 9
Garcia-Munoz Rodrigo, 2014 CA 4 2 3 9
Gawade, 2013 IVH 3 0 3 6 No CA definition, no adjustment
Gonzalez-Luis, 2002 CA 4 0 3 7 No adjustment
Gray, 1997 CA 4 0 3 7
Hendson, 2011 CA 4 0 3 7 No adjustment
Hitti, 2001 CA 4 0 3 7 No adjustment
Holcroft, 2003 IVH 2 0 3 5 No IVH definition, no adjustment
Kallankari, 2010 IVH 4 0 3 7 No adjustment
Kaulkola,2006 IVH 4 0 3 7 No adjustment
Kidokoro IVH 4 1 3 8 Only adjusted for 1 factor
Kim, 2015 CA 4 0 3 7 No adjustment
Kirchner, 2007 CA 4 0 3 7 No adjustment
Klebermans-Schrehof IVH 4 0 3 7 No adjustment
Kosuge, 2000 CA 4 0 2 6 No IVH definition, no adjustment
Lau, 2005 CA 4 0 3 7 No adjustment
Lee Hyun Ju, 2011 CA 4 0 3 7 No adjustment
Lee Ju Young, 2010 IVH 4 1 3 8 Only adjusted for 1 factor
Lim, 2011 IVH 4 2 3 9
Linder, 2003 IVH 4 2 3 9
Liu, 2014 CA 4 0 3 7 No adjustment
Logan, 2013 IVH 4 0 3 7 No adjustment
Lu, 2016 IVH 4 0 3 7 No adjustment
Mehta, 2006 CA-IVH 4 0 3 7 No adjustment
Mestan, 2010 CA 4 0 3 7 No adjustment
Miyazaki, 2016 CA 4 2 3 9
Morales, 1987 CA 4 0 3 7 No adjustment
Mu, 2008 CA 4 1 3 8 Only adjusted for 1 factor
Nasef, 2013 CA 4 0 3 7 No adjustment
Ogunyemi, 2003 CA 4 0 3 7 No adjustment
Oh, 2015 IVH 4 2 3 9
Oh, 2018 CA 4 2 3 9
Ohyama, 2002 CA 4 0 2 6 No IVH definition, no adjustment
Osmanagaoglu, 2005 CA 4 0 3 7 No adjustment
Pappas, 2014 CA 4 0 2 6 No IVH definition, no adjustment
Perrone, 2012 CA 4 0 3 7 No IVH definition
Polam, 2005 CA 4 0 2 6 Loss to follow up, no adjustment
Poralla, 2012 IVH 4 0 2 6 No IVH definition
Richardson, 2006 CA 4 0 2 6 No IVH definition, no adjustment
Rocha, 2006 & Rocha, 2007 CA 4 2 3 9
Rodríguez-Trujillo, 2016 CA 4 0 3 7 No adjustment
Rong, 2012 IVH 4 2 2 8 No CA definition
Ryckman, 2011 IVH 3 0 3 6 No CA definition, no adjustment
Salas, 2013 CA 4 0 3 7 No adjustment
Sarkar, 2005 CA-IVH 4 0 3 7 No adjustment
Sato, 2011 CA 4 1 2 7 No IVH definition, only adjusted for 1 factor
Seliga-Siwecka, 2013 CA 4 2 3 9
Shankaran, 2014 IVH 4 2 2 8
Smit, 2015 CA 4 0 3 7 No adjustment
Soraisham, 2009 CA 4 2 3 9
Soraisham, 2013 CA 4 0 2 6 Loss to follow up, no adjustment
Suarez, 2001 IVH 4 0 3 7 No adjustment
Suppiej, 2009 CA 4 0 2 6 Loss to follow up, no adjustment
Trevisanuto, 2010 CA 4 1 3 8 Only adjusted for 1 factor
Tsiartas, 2013 CA 4 0 3 7 No adjustment
Vaihinger, 2013 IVH 4 2 3 9
van Vliet, 2012 CA 4 0 2 6 No adjustment
Vergani, 2004 IVH 4 0 3 7 No adjustment
Watterberg, 1999 CA 4 0 3 7 No adjustment
Wirbelauer, 2011 CA 4 0 3 7 No adjustment
Xu, 2012 CA 4 0 3 7 No adjustment
Yamada, 2015 CA 4 0 3 7 No adjustment
Yanowitz, 2006 CA 4 0 3 7 No adjustment
Yoon, 1995 CA 4 0 3 7 No adjustment
Zanardo, 2008 CA-IVH 4 0 3 7 No adjustment

Select., selection; Comp., comparability; Outc., outcome; CA, chorioamnionitis; IVH, intraventricular hemorrhage.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.


Articles from Frontiers in Physiology are provided here courtesy of Frontiers Media SA

RESOURCES