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. 2019 Jan 9;68(3):502–514. doi: 10.2337/db18-0418

Figure 4.

Figure 4

ADAMTS9 overexpression modulates integrin signaling, cytoskeletal proteins, and capillary density. A, B, and D: Mouse TA muscles overexpressing WT-ADAMTS9, mut-ADAMTS9, or control plasmid were isolated at 10 weeks of age and used for Western blot analyses (n = 13 for WT-ADAMTS9 and control groups [n = 11 for control group for PINCH], n = 14 for mut-ADAMTS9; results replicated twice and then pooled) (A and B) and mRNA expression levels of desmin2 and MYH2 normalized to TBP (desmin2: n = 8 for all groups; MYH2: n = 8 for control, n = 7 for WT-ADAMTS9 and mut-ADAMTS9) (D). C: Mouse TA muscles overexpressing ADAMTS9 or control plasmid were isolated at 10 weeks of age and used for Western blot analysis (n = 12 for each group). Statistical significance was determined using one-way ANOVA with Tukey test for multiple comparisons (A, B, and D) or paired Student t test (C). *P < 0.05, **P < 0.01 for genotype effect. A.U., arbitrary units.