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. 2018 Sep 8;37(2):141–153. doi: 10.1007/s40273-018-0708-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Illustration of the full progression-free survival (PFS) to overall survival (OS) surrogacy approach. PD progressive disease, PFS1 first-line progression-free survival, PFS2 second-line progression-free survival.

Source: company submission, Fig. 20, p. 102