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. Author manuscript; available in PMC: 2020 Feb 12.
Published in final edited form as: Biochemistry. 2018 Dec 18;58(6):438–449. doi: 10.1021/acs.biochem.8b01004

Figure 1: The inter-connection between protein structure, dynamics and function has significance for improving catalytic efficiency of enzymes.

Figure 1:

The active-site region provides environment with optimal electrostatics to promote the catalyzed reaction. Several enzymes contain conserved networks of residues that connect surface regions to the active-site. These networks provide thermo-dynamical coupling between the hydration-shell and bulk solvent, and the catalyzed reaction. The discovery of these enzyme energy networks allows new strategies for increasing the catalytic efficiency through enhancing the energy flow through these networks and optimization through mutations.