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. 2019 Feb 22;6(1):ENEURO.0389-18.2019. doi: 10.1523/ENEURO.0389-18.2019

Figure 2.

Figure 2.

DCA injection reduces the phosphorylation of PDH in the frontal cortex and hippocampus. A, B, Western blot analysis (left) was performed on extracts from the frontal cortex (A) and the hippocampus (B) of mice intraperitoneally injected with either saline or DCA (200 mg/kg) 30 min before being killed. Densitometric analysis of Western blots (right) revealed significantly lower PDH phosphorylation in DCA-treated mice relative to saline-injected mice (*p < 0.05, ***p < 0.001; n = 6 and 6, respectively, for extracts from the frontal cortex of saline- and DCA-injected mice; and n = 7 and 7, respectively, for extracts from the hippocampus of saline- and DCA-injected mice). Band densities were standardized to β-actin controls. Data shown are the mean ± SEM.