TABLE 1.
Complete set of all mutations within the cloned RN18 analog-resistant virus
| HIV-1LAI genomic region | Mutation(s) | Notes |
|---|---|---|
| LTR | C17T, C9007A | TARa element stem (C17T), LEF-1 binding site (C9007A) |
| Gag | E12K, E40K, I223T, R361K | Protease inhibitor resistance |
| Pol p66 | L491V | RNaseH |
| Vif | V142I | Elongin C, A3G binding |
| Vpr | W38stop | Vpr inactivation |
| Env | N306K, E434K, I520M, R538A, Q555H, A583T, K660E | Likely inherent Env variability |
| Nef | E59K, C206stop | Loss of last Nef amino acid |
a
TAR, trans-activation response element.