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. 2018 Sep 27;104(3):485–496. doi: 10.3324/haematol.2018.197749

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Figure 3. — DUSP1 is an NRF2 target gene in myelodysplastic syndrome (MDS). (A) Gene set enrichment plot showed that NRF2 target genes were enriched in cytarabine (Ara-C)--resistant acute myeloid leukemia (AML) patients. (B) Overlap of up-regulated NRF2 target genes in higher-risk MDS patients and Ara-C-resistant AML patients. (C) The gene list of 37 overlapped genes. (D) ChIP sequence analysis of published data²⁴ indicated the NRF2 binding site in the region of DUSP1 gene. (E) NRF2 binding sites in the regions of NQO1 and DUSP1 genes. TSS: transcription start site; TTS: transcription termination site. (F) NRF2 ChIP q-PCR analysis of SKM-1 cells.