Table 1.

Lead variants at loci associated with FVII activity when excluding studies that measured FVII antigen from the trans-ancestry meta-analysis

Variant rsID	Chr:Pos*	Alleles†	Freq‡	Freq EA§	Freq AA||	β	SE	P	Variance explained, %	Closest gene	Annotation	Discovery status
rs569557	13:113769917	G/A	0.88	0.88	0.88	0.157	0.003	6.4 × 10−600	13.9	F7	Intronic	Known
rs867186	20:33764554	G/A	0.10	0.11	0.09	0.057	0.003	3.3 × 10−64	1.6	PROCR	Missense	Known
rs1260326	2:27730940	T/C	0.39	0.41	0.15	0.024	0.002	2.3 × 10−30	0.7	GCKR	Missense	Known
rs7935829	11:59942815	G/A	0.39	0.40	0.21	0.018	0.002	6.3 × 10−18	0.4	MS4A6A	Intronic	Known
rs6532796	4:100042242	G/A	0.70	0.69	0.83	0.016	0.002	2.6 × 10−13	0.3	ADH4	Downstream	Known
rs1149616	11:76498369	T/C	0.17	0.17	0.16	0.017	0.003	1.7 × 10−10	0.2	TSKU	Intronic	Known
rs10761784	10:65308750	A/T	0.53	0.51	0.67	0.013	0.002	6.7 × 10−10	0.2	REEP3	Intronic	Novel
rs498475	7:28256240	G/A	0.42	0.38	0.74	0.012	0.002	1.5 × 10−8	0.2	JAZF1-AS1	ncRNA	Novel

The variance explained shown in this table was calculated using the sample size weighted mean variance of log-transformed FVII and the betas and frequencies from the trans-ancestry meta-analysis summary statistics.

AA, African ancestry; Chr, chromosome; EA, European ancestry; Freq, frequency; ncRNA, noncoding RNA; Pos, position; rsID, reference SNP cluster ID; SE, standard error.

^*The Chr:Pos column shows the chromosome and position (build 37).

^†The Alleles column shows the FVII-increasing allele/FVII-decreasing allele.

^‡The Freq column shows the frequency of the FVII-increasing allele.

^§The Freq EA column shows the frequency specifically in participants of European ancestry.

^||The Freq AA column shows the frequency specifically in participants of African ancestry.