Figure 4. Interaction of AD pathology and hippocampal sclerosis with episodic memory.

The association of AD pathology and hippocampal sclerosis with episodic memory as a function of years before death from a time-varying effect model adjusted for age at death, education, sex, gross infarcts, microinfarcts, TDP-43 pathology, Lewy bodies, cerebral amyloid angiopathy, atherosclerosis, and arteriolar sclerosis. The black dotted line shows the initial cognitive-pathologic association and the red dotted line (with blue shading indicating the 95% confidence interval) shows the cognitive-pathologic association as a function of years before death. AD = Alzheimer disease; HS = hippocampal sclerosis; TDP-43 = transactive response DNA-binding protein 43.