Scheme 7. The synthesis of compound 4b. Reagents and conditions: (a) SOCl2, CH3OH, room temperature; (b) NaH, DMSO, 120 °C, 24 h; (c) NaOH, EtOH/H2O, room temperature, 2 h, then 3 N HCl; (d) EDCI, pyrrolidine, Et3N, CH2Cl2, 50 °C, 4 h.
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