Table 2.
The 4-protein logistic regression classifier (P4) for HBV-ACLF diagnosis.
| Gene | Protein | ACLF/CHB Ratio* | Function | ROC analysis | Logistic regression | ||||
|---|---|---|---|---|---|---|---|---|---|
| auROC | Sen. | Spe. | Coef. | P-value | |||||
| APOC3 | Apolipoprotein C-III | 0.11 | Lipid/cholesterol transport and metabolism (VLDL components) | 0.956 | 0.944 | 0.88 | -0.92085 | 0.0003 | |
| HRG | Histidine-rich glycoprotein | 0.18 | immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis | 0.914 | 0.817 | 0.88 | -0.75754 | 0.0236 | |
| TF | Serotransferrin (Beta-1 metal-binding globulin, Siderophilin) |
0.42 | iron transport/storage | 0.84 | 0.817 | 0.761 | 1.20517 | 0.0154 | |
| KLKB1 | Kallikrein | 0.12 | coagulation regulation, Kinin-renin-angiotensin system | 0.864 | 0.915 | 0.707 | -0.52709 | 0.0030 | |
| Constant | - | - | - | - | - | - | 17.0668 | - | |
| Summary of diagnosis performance of P8 logistic regression classifier | |||||||||
| Cut-off value | ROC-AUC | Sen. | Spe. | J | |||||
| 0.3139 | 0.961 | 0.9437 | 0.8913 | 0.835 | |||||
*all markers shown t-test Bonferroni-adjusted P<0.0001