Table 1.

Summary of the reviewed predictors for lysine succinylation sites.

Tools	SucPred	iSuc-PseAAC	SuccFind	iSuc-PseOpt	pSuc-Lys	SucStruct	PSSM-Suc	SuccinSite	SuccinSite2.0	SSEvol-Suc	Success	GPSuc
Species	Generic	Generic	Generic	Generic	Generic	Generic	Generic	Generic	Generic and Species-specific	Generic	Generic	Generic and Species-specific
Web-server link	http://59.73.198.144:8088/SucPred/	http://app.aporc.org/iSuc-PseAAC/	http://bioinfo.ncu.edu.cn/SuccFind.aspx	http://www.jci-bioinfo.cn/iSuc-PseOpt	http://www.jci-bioinfo.cn/pSuc-Lys	https://github.com/YosvanyLopez/	https://github.com/YosvanyLopez/PSSM-Suc	http://systbio.cau.edu.cn/SuccinSite/	https://biocomputer.bio.cuhk.edu.hk/SuccinSite2.0/	https://github.com/YosvanyLopez/SSEvol-Suc	https://github.com/YosvanyLopez/Success	http://kurata14.bio.kyutech.ac.jp/GPSuc/
Working server	No	Yes	No	No	No	No	No	Yes	Yes	No	No	Yes
Machine learning	SVM	SVM	SVM	RF	RF	DT	DT	RF	RF	AdaBoost	SVM	RF and LR
Dataset size (Protein/succinylated)	897/2511	896/2521	1044/2938	896/2521	896/2521	670/1782	670 / 1782	2322/5004	2322/5004	670/1782	670/1782	2322/5004
Training (Pos/Neg)	1436/18,958	1167/3553	2713/23598	1167/3553	1167/3553	1782/1872	1782/1643	4750/9500	4750/9500	1782/1872	1782/1872	4750/9500
Independent (Pos/Neg)	250/-	-	-	-	-	-	-	254/2977	254/2977	-	-	254/2977
Homolog redundancy	35%	40%	30%	40%	40%	40%	40%	30%	30%	40%	40%	30%
Window size	from −9 to +9	from −7 to +7	from −10 to +10	from −15 to +15	from −15 to +15	from −15 to +15	from −15 to +15	from −13 to +13	from −20 to +20	from −15 to +15	from −15 to +15	from −20 to +20
Adjusted batch prediction	NO	No	No	No	No	No	No	Yes	Yes	No	No	Yes
Processing time for a protein	-	Within 20 s	-	-	-	-	-	Within 20 s	Within 5 min	-	-	Within 5 min