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. 2019 Feb 20;7(2):56. doi: 10.3390/microorganisms7020056

Figure 2.

Figure 2

Alignment of the VapCs of L. interrogans serovar Copenhageni. Alignment was done using the COBALT tool (Constraint-based Multiple Alignment Tool), which aligns the sequences via considering the amino acid sequence and protein domains. The numbers of VapCs in parentheses are based on the numerical order of the genes in the chromosome and refer to the loci described in Table 1. The highlighted acidic amino acids comprise the residues essential to the catalytic activity and classification within the PIN (PilT N-terminal) domain.